The unique physiology of the lungs necessitates special considerations for developing a
robust and discriminate dissolution method for orally inhaled drug products (OIDPs). Despite …

Almost all current orally inhaled drug products (OIDPs) are for the treatment of respiratory
diseases, and many have been designed using molecular or formulation strategies to retain …

In vitro dissolution and permeability testing aid the simulation of the in vivo behavior of
inhalation drug products. Although the regulatory bodies have specific guidelines for the …

Dissolution testing is routinely used for quality control purposes to test batch‐to‐batch
consistency, stability and detect manufacturing deviations of pharmaceutical products. While …

The purpose of this article is to review the suitability of the analytical and statistical
techniques that have thus far been developed to assess the dissolution behavior of particles …

In vitro dissolution testing is routinely used in the development of pharmaceutical products.
Whilst the dissolution testing methods are well established and standardized for oral dosage …

Pulmonary dissolution of poorly soluble drug substances (DSs) may limit the drug
absorption rate and consequently influence clinical performance. Dissolution rate is thus an …

Inhalation is the preferred route for the treatment of lung diseases. More recently, also
formulations for systemic treatment have been developed. For efficient development of …

The dissolution of inhaled drug particles in the lungs is a challenge to model using
biorelevant methods in terms of (i) collecting a respirable emitted aerosol fraction and …

The main purpose of this work was to develop an in vitro method for simulating the
dissolution and absorption of inhaled dry powder drugs that also mimics systemic …