M any depressed patients do not remit on antidepressant medication despite an adequate
dosage and a sufficient duration of treatment. 1 This has spawned endeavors to define …

There is considerable diversity in how treatment-resistant depression (TRD) is defined.
However, every definition incorporates the concept that patients with TRD have not …

The effectiveness of treatments for depression is suboptimal for a significant portion of
individuals diagnosed with depressive illnesses. 1 At least 20% do not respond satisfactorily …

The good news is that advances in the treatment of depression in the past decade have led
to better recognition of those with depression, and also to a reduction in the number of …

A reliable and valid instrument has yet to be developed that elicits antidepressant treatment
history via patient interview. The goal of the present study was to establish the test-retest …

Treatment-resistant depression (TRD) is a common clinical occurrence among patients
treated for major depressive disorder. However, a clear consensus regarding the criteria …

The goal of antidepressant treatment is full remission, but adverse events prevent many
patients from reaching and sustaining this goal. Differential diagnosis should be made …

The main goal of treatment in patients with mood disorders is usually to restore a state of
psychological wellness and high functioning. Although many depressed patients do improve …

The low rate of response to antidepressants in treatment resistant depression (TRD) justifies
studies of next‐step therapies following a treatment failure. In TRD clinical trials, it is …

Full symptomatic remission is the optimal outcome for patients with major depression.
Unfortunately, initial antidepressant efficacy is limited to partial response for many patients …