Cellular fate is determined by transcriptional networks and epigenetic states. In addition to
protein factors, noncoding RNAs (ncRNAs), particularly microRNAs and long ncRNAs, are …

Abstract In mammals, short (mi-) and long non-coding (lnc) RNAs are immensely abundant
and they are proving to be more functional than ever before. Particularly in cell …

Cellular homeostasis is achieved by the proper balance of regulatory networks that if
disrupted can lead to cellular transformation. These cell circuits are fine-tuned and …

Pluripotent stem cells have great potential for developmental biology and regenerative
medicine. Embryonic stem cells, which are obtained from blastocysts, and induced …

Lineage specification in early development is the basis for the exquisitely precise body plan
of multicellular organisms. It is therefore critical to understand cell fate decisions in early …

In recent years, long noncoding RNAs (lncRNAs) have emerged as an important class of
regulators of gene expression. lncRNAs exhibit several distinctive features that confer …

Differentiation of specialized cell types from stem and progenitor cells is tightly regulated at
several levels, both during development and during somatic tissue homeostasis. Many long …

Recent advances in high-throughput technologies have revealed that although major
portions of genomes in all eukaryotes transcribe, only a very small fraction of the transcripts …

Cell fate decision is a critical step during physiological development when embryonic stem
cells commit to either becoming adult stem cells or somatic cells. Recent advances in …

The term “non-coding RNA”(ncRNA) is generally used to indicate RNA that does not encode
a protein and includes several classes of RNAs, such as microRNA and long non-coding …