When an antidepressant fails to help a depressed patient, clinicians are faced with the
daunting task of choosing the next treatment. Several pharmacologic and nonpharmacologic …

AIM: To review evidence supporting pharmacological treatments for treatment-resistant
depression (TRD) and to discuss them according to personal clinical experience …

Major depressive disorder is a frequent, serious disorder that usually responds partially to
treatment and leaves many patients with treatment resistance. This article reviews and …

The development of new classes of antidepressant medications in the past few decades has
clearly revolutionized the treatment of major depression. At the same time, it also has …

Limitations by JOHN P. O'REARDON, MD; and JAY D. AMSTERDAM, MD lthough the
therapeutic armament-arium available for the clinician treating major depression has …

Although the therapeutic armamentarium available for the clinician treating major
depression has expanded substantially over the last decade, the percentage of patients with …

Our ability to treat depression has improved with the availability of receptor-specific and
chemically diverse groups of antidepressants. Even now, most of the short-term studies …

The management of patients with depression who have failed to respond to antidepressant
medication is a common problem in general and old age psychiatry. It has been estimated …

Abstract Treatment-resistant depression, or difficult-to-treat depression is emerging as a
focus of scientific endeavor. Serotonin reuptake inhibitors and serotonin norepinephrine …

Major depressive disorder is a debilitating disease that imposes significant social and
economic burdens not only on patients but also on society. Although various treatment …