Purpose The ability of two semi-mechanistic simulation approaches to predict the systemic
pharmacokinetics (PK) of inhaled corticosteroids (ICSs) delivered via dry powder inhalers …

Correlating data from in vitro dissolution testing of inhaled particulate pharmaceuticals or air
pollutants with the dissolution and distribution to the blood circulation of the same aerosols …

The aim of this study was to further evaluate and optimize the Transwell® system for
assessing the dissolution behavior of orally inhaled drug products (OIDPs), using fluticasone …

Poorly water‐soluble drugs represent the major part of the current and future market. Drug
insolubility could impair the absorption through biological membranes and/or the …

The aim of the study was to develop a robust and standardized in vitro dissolution
methodology for orally inhaled drug products (OIDPs). An aerosol dose collection (ADC) …

ABSTRACT The US Pharmacopeia (USP) contains standards for tests, procedures, and
acceptance criteria for inhalation dosage forms that are administered orally and intranasally …

Importance of the field: Successful respiratory drug delivery for local and systemic purposes
is predicated on the availability of in vitro and in vivo methods for determining drug delivery …

We combined high-energy wet media milling and spray drying to engineer dry powders for
inhalation consisting of geometrically large, low-density particles with superior aerodynamic …

Purpose To develop a unique in vitro aqueous fluid-capacity-limited dissolution system for
the kinetic assessment of respirable aerosol drug particles from inhaler products. Methods …

Glucocorticoids administered by inhalation remain a first-line treatment of patients with
asthma allergic rhinitis and advanced chronic obstructive pulmonary disease. Budesonide …