Purpose An improved, simple apparatus was developed to easily and uniformly disperse dry
powders onto an air-liquid interfaced cultured cell layer. We investigated drug permeation in …

The generation of inhalable sized particles (1–5 μm) usually involves a particle-processing
step; most commonly milling but spray drying has shown to be a suitable alternative …

The pulmonary route has long been used for drug administration for both local and systemic
treatment. It possesses several advantages, which can be categorized into physiological, ie …

Drug absorption is a complex process involving dissolution and precipitation, along with
other kinetic processes. The purpose of this work was to (1) establish an in vitro …

The portfolio of compounds approved for inhalation therapy has expanded rapidly for
treatment of lung diseases. To assess the efficacy and safety of inhaled medicines, a better …

Interactions between drug particulates are crucial in determining drug dispersion and
deaggregation, and ultimately delivery efficiency. This book combines principles established …

The nasal physiology offers great potential for drug delivery but also poses specific
challenges, among which the short residence time of applied drugs is one of the most …

Dissolution has become an indispensable tool to predict the in vivo performance of dosage
form, especially in recent times, because of the increasing complexity of new drugs …

Biorelevant fluids are required to enable meaningful in vitro experimental determinations of
the biopharmaceutical properties of inhaled medicines, eg drug solubility, particle …

Large porous particles are becoming increasingly popular as carriers for pulmonary drug
delivery with both local and systemic applications. These particles have high geometric …