It has long been desired to match airflow conditions during formulation evaluation to those of
relevance to lung deposition. In this context several strategies have been adopted involving …

Compared with oral and parenteral formulations, inhaled formulations are attractive because
of their great benefit and potential to enhance therapeutic effects of medications. Among the …

Delivery of therapeutic agents via the pulmonary route has gained significant attention over
the past few decades because this route of administration offers multiple advantages over …

Solid dispersions are one of the most promising strategies to improve the oral bioavailability
of poorly water soluble drugs. By reducing drug particle size to the absolute minimum, and …

Purpose A fundamental approach incorporating current theoretical models into aerosol
formulation design potentially reduces experimental work for complex formulations. A D …

The development of a meaningful dissolution procedure for drug products with limited water
solubility has been a challenge to both the pharmaceutical industry and the agencies that …

Pulmonary administration of drugs presents several advantages in the treatment of many
diseases. Considering local and systemic delivery, drug inhalation enables a rapid and …

We introduce a “hierarchical” modeling strategy designed to be systematically extensible to
increase the detail of dissolution predictions from polydisperse collections of drug particles …

Respiratory tract is one of the oldest routes for drug delivery. It can be used for local and
systemic drug deliveries. Inhalation therapy has several advantages over oral. It delivers the …

The purpose of this article is to inform the dissolution scientist of a powerful emerging tool
that provides in vivo linkage to dissolution methods. This tool is physiologically based …