Correlating data from in vitro dissolution testing of inhaled particulate pharmaceuticals or air
pollutants with the dissolution and distribution to the blood circulation of the same aerosols …

The dissolution of inhaled drug particles in the lungs is a challenge to model using
biorelevant methods in terms of (i) collecting a respirable emitted aerosol fraction and …

The main purpose of this work was to develop an in vitro method for simulating the
dissolution and absorption of inhaled dry powder drugs that also mimics systemic …

The surface area of the air/liquid interface in the lungs is substantial, so deposited doses of
aerosol medicines per interface surface area when administered via the inhalation route is …

Many inhaled drugs are poorly water soluble, and the dissolution rate is often the rate-
limiting step in the overall absorption process. To improve understanding of pulmonary drug …

Pulmonary dissolution of poorly soluble drug substances (DSs) may limit the drug
absorption rate and consequently influence clinical performance. Dissolution rate is thus an …

In vitro dissolution and permeability testing aid the simulation of the in vivo behavior of
inhalation drug products. Although the regulatory bodies have specific guidelines for the …

Inhalation is the preferred route for the treatment of lung diseases. More recently, also
formulations for systemic treatment have been developed. For efficient development of …

The aim of this research was to investigate a potential standardized test method to
characterize the dissolution properties of formulations intended for pulmonary delivery. A …

The unique physiology of the lungs necessitates special considerations for developing a
robust and discriminate dissolution method for orally inhaled drug products (OIDPs). Despite …