The concept of treatment-resistant or treatment-refractory depression (TRD) has evolved
over 40 years since the recognition that some patients minimally benefit from repeated …

Treatment-resistant depression (TRD) is a common clinical occurrence among patients
treated for major depressive disorder. However, a clear consensus regarding the criteria …

Managing patients with treatment-resistant depression (TRD) remains a major challenge for
the practicing physician. Depression is considered treatment-resistant when at least two …

Treatment-resistant depression (TRD) is a major public health problem in terms of its
prevalence and in terms of individual suffering and cost to society. Best estimates indicate …

The effectiveness of treatments for depression is suboptimal for a significant portion of
individuals diagnosed with depressive illnesses. 1 At least 20% do not respond satisfactorily …

Objective: Up to 15% of depression patients eventually present with treatment-resistant or
refractory depression (TRD), a condition that causes significant social and economic …

Limitations by JOHN P. O'REARDON, MD; and JAY D. AMSTERDAM, MD lthough the
therapeutic armament-arium available for the clinician treating major depression has …

Background. The failure to achieve remission for patients with Major Depressive Disorder
(MDD) represents a major public health concern. Inadequately treated depression is …

Treatment‐resistant depression (TRD) is common and associated with multiple serious
public health implications. A consensus definition of TRD with demonstrated predictive utility …

Forty to 50% of depressed patients who are initially prescribed antidepressant medications
or administered electroconvulsive therapy do not experience a timely remission. This group …