Major depressive disorder is a frequent, serious disorder that usually responds partially to
treatment and leaves many patients with treatment resistance. This article reviews and …

When an antidepressant fails to help a depressed patient, clinicians are faced with the
daunting task of choosing the next treatment. Several pharmacologic and nonpharmacologic …

The management of patients with depression who have failed to respond to antidepressant
medication is a common problem in general and old age psychiatry. It has been estimated …

Abstract Treatment-resistant depression, or difficult-to-treat depression is emerging as a
focus of scientific endeavor. Serotonin reuptake inhibitors and serotonin norepinephrine …

AIM: To review evidence supporting pharmacological treatments for treatment-resistant
depression (TRD) and to discuss them according to personal clinical experience …

Major depressive disorder is a debilitating disease that imposes significant social and
economic burdens not only on patients but also on society. Although various treatment …

Little systematic attention has been directed toward the subject of treatment-resistant
depression. Although these patients constitute a distinct minority, their treatment consumes a …

Although the therapeutic armamentarium available for the clinician treating major
depression has expanded substantially over the last decade, the percentage of patients with …

Recent clinical investigations have revealed that a substantial proportion of patients with
depression do not have a satisfactory therapeutic outcome with an initial treatment attempt …

As many as 30% of depressed patients fail to respond to treatment with an antidepressant
and at least 60% to 75% may fail to achieve complete remission. 57 In its broadest form …