Maintenance of the pluripotent state or differentiation of the pluripotent state into any germ
layer depends on the factors that orchestrate expression of thousands of genes through …

Pluripotency refers to the self‐renewal of undifferentiated embryonic stem cells (ESCs), and
is maintained by a tightly regulated gene regulatory network involving an intricate interplay …

There is increasing evidence that long noncoding RNAs (lncRNAs) are among the main
regulatory factors of stem cell maintenance and differentiation. They act through various …

Pluripotent stem cells (PSCs) represent a unique kind of stem cell, as they are able to
indefinitely self‐renew and hold the potential to differentiate into any derivative of the three …

Pluripotent stem cells have broad applications in regenerative medicine and offer ideal
models for understanding the biological process of embryonic development and specific …

The most part of our genome encodes for RNA transcripts are never translated into proteins.
These include families of RNA molecules with a regulatory function, which can be arbitrarily …

LncRNAs have recently emerged as new and fundamental transcriptional and post-
transcriptional regulators acting at multiple levels of gene expression. Indeed, lncRNAs …

Because of their capability of differentiation into lineage‐specific cells, stem cells are an
attractive therapeutic modality in regenerative medicine. To develop an effective stem cell …

Embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) hold immense
promise for regenerative medicine due to their abilities to self-renew and to differentiate into …

Over the past decade, genome‐wide transcriptomic studies have shown that the mammalian
genome is pervasively transcribed and produces many thousands of transcriptomes without …