The effectiveness of treatments for depression is suboptimal for a significant portion of
individuals diagnosed with depressive illnesses. 1 At least 20% do not respond satisfactorily …

Treatment-resistant depression (TRD) is a major public health problem in terms of its
prevalence and in terms of individual suffering and cost to society. Best estimates indicate …

Full symptomatic remission is the optimal outcome for patients with major depression.
Unfortunately, initial antidepressant efficacy is limited to partial response for many patients …

Limitations by JOHN P. O'REARDON, MD; and JAY D. AMSTERDAM, MD lthough the
therapeutic armament-arium available for the clinician treating major depression has …

Clinical trials indicate that over 50% of depressed patients show an inadequate response to
antidepressant therapy, and that incomplete recovery from major depressive disorder (MDD) …

Objectives: Very few studies have investigated clinical features associated with treatment-
resistant depression (TRD) defined as failure of at least 2 consecutive antidepressant trials …

The main goal of treatment in patients with mood disorders is usually to restore a state of
psychological wellness and high functioning. Although many depressed patients do improve …

Treatment-resistant depression (TRD) is a common clinical presentation responsible for
much of the burden of major depressive disorder worldwide. For this reason, TRD requires …

Major depressive disorder is a debilitating disease that imposes significant social and
economic burdens not only on patients but also on society. Although various treatment …

Background Varying conceptualizations of treatment‐resistant depression (TRD) have made
translating research findings or systematic reviews into clinical practice guidelines …