Treatment-resistant depression is commonly encountered by mental health professionals.
This is accounted for, in part, by the referral of resistant patients for treatment. But, in …

Treatment resistant depression (TRD) is a serious public health problem. It is estimated that
around 20-40% of patients with a major depressive episode (whether monopolar or bipolar) …

Objective: Many patients with depression remain poorly responsive to antidepressant
monotherapy. One approach for managing treatment-resistant depression is to combine …

In the evaluation of treatment‐resistant or treatment‐refractory depression (TRD), true
resistance to antidepressant therapy must be distinguished from inadequate dose, duration …

BACKGROUND: Treatment-resistant depression (TRD) is relatively common and accounts
for a large proportion of the overall burden caused by depression. We conducted a …

Background Patients with major depression respond to antidepressant treatment, but 10%–
30% of them do not improve or show a partial response coupled with functional impairment …

Therapy-resistant depression is not untreatable. Numerous treatment methods with
substantiated effectiveness exist. However, none of them are able to ensure remission …

One in three adults with major depressive disorder (MDD) do not experience clinically
significant improvement after multiple sequential courses of antidepressants and have …

Now, more than ever before, a wealth of options exists for depressed patients who do not
benefit from treatment with standard, first-line antidepressant agents. In this paper, alternate …

The management of patients with depression who have failed to respond to antidepressant
medication is a common problem in general and old age psychiatry. It has been estimated …