Little systematic attention has been directed toward the subject of treatment-resistant
depression. Although these patients constitute a distinct minority, their treatment consumes a …

Background Most adults with major depressive disorder (MDD) fail to achieve remission with
index pharmacological treatment. Moreover, at least half will not achieve and sustain …

Approximately 30% of people treated for a major depressive episode will not achieve
remission after two or more treatment trials of first-line antidepressants and are considered …

OBJECTIVE: Identifying predictors of outcome among patients with treatment-resistant
depression (TRD) is challenging. We hypothesised that discrepancy between self-rated and …

Depression is the fourth-largest contributor to the global burden of disease, and it causes
profound suffering and extreme costs to health care systems and society. Although there …

Raw Data Raw data consist of such items as a copy of a patient medical record or a
pharmacy computer output. These should be obtained with patient consent and incorporated …

As descriptors for the clinical course and treatment of depressive illness, terms such as
response, remission, and recovery have evolved with our understanding of the disease, yet …

Background Treatment‐resistant depression (TRD) is a debilitating chronic mental illness
that confers increased morbidity and mortality, decreases the quality of life, impairs …

The good news is that advances in the treatment of depression in the past decade have led
to better recognition of those with depression, and also to a reduction in the number of …

OBJECTIVE: Antidepressant efficacy trials use multiple exclusion criteria that are intended
primarily to maximize differences between the drug and placebo. These exclusion criteria …