Abstract Treatment-Resistant Depression (TRD) represents a source of ongoing clinical and
nosological controversy and confusion. While no univocal consensus on its definition and …

The dilemma of developing new medications rationally--as opposed to discovering them
through serendipity--is to create an optimal balance between the number of mechanisms of …

Objectives: Timing issues of antidepressant drug response are of major clinical relevance,
given our current inability to predict when a particular patient will respond to a particular …

What variables predict who should be treated with antidepressants and who should not? If
someone should be treated, what variables predict which treatment is most likely to work? If …

The purpose of this work was to study the prevalence of somatic symptoms in patients with
treatment-resistant depression (TRD) and their impact on the response to antidepressant …

This prospective study assessed the influence of resistance to antidepressant
pharmacotherapy on the short-term response to subsequent electroconvulsive therapy …

In recent years there has been a considerable debate on antidepressant drugs. Continued
drug treatment with antidepressant medications may stimulate processes that run counter to …

Long-term antidepressant treatment has increased and there is evidence of adverse effects;
however, little is known about patients' experiences and views of this form of treatment. This …

Recent research suggests that there may be a reduction in therapeutic response after
multiple administrations of antidepressant drug (AD) therapy in patients with major …

Objective Traditionally, it has been widely assumed that the likelihood of response to ECT is
independent of the adequacy of previous treatment with antidepressant medications …