What is the meaning of treatment resistant/refractory major depression (TRD)? A systematic review of current randomized trials

MT Berlim, G Turecki - European Neuropsychopharmacology, 2007 - Elsevier
OBJECTIVE: To summarize and discuss the conceptual and operational definitions of
treatment resistant/refractory depression (TRD) by systematically reviewing randomized …

Current trends in the assessment and somatic treatment of resistant/refractory major depression: an overview

MT Berlim, MP Fleck, G Turecki - Annals of medicine, 2008 - Taylor & Francis
A significant proportion of depressed patients eventually present with treatment‐
resistant/refractory major depression (TRD), a debilitating condition that imposes significant …

Treatment resistant depression: methodological overview and operational criteria

D Souery, J Amsterdam, C De Montigny… - European …, 1999 - Elsevier
A wide variety of definitions are used for Treatment Resistant Depression (TRD), considering
various criteria and different concepts. Some of the key issues are: the diagnosis, the …

Definition, assessment, and staging of treatment—resistant refractory major depression: a review of current concepts and methods

MT Berlim, G Turecki - The Canadian Journal of Psychiatry, 2007 - journals.sagepub.com
Objective: Up to 15% of depression patients eventually present with treatment-resistant or
refractory depression (TRD), a condition that causes significant social and economic …

Treatment-resistant depression

D Souery, GI Papakostas, MH Trivedi - Journal of Clinical …, 2006 - psychiatrist.com
Treatment-resistant depression (TRD) is a common clinical occurrence among patients
treated for major depressive disorder. However, a clear consensus regarding the criteria …

Defining treatment‐resistant depression

BN Gaynes, L Lux, G Gartlehner, G Asher… - Depression and …, 2020 - Wiley Online Library
Background Varying conceptualizations of treatment‐resistant depression (TRD) have made
translating research findings or systematic reviews into clinical practice guidelines …

[HTML][HTML] Definition of treatment-resistant depression–Asia Pacific perspectives

CH Ng, T Kato, C Han, G Wang, M Trivedi… - Journal of affective …, 2019 - Elsevier
Background The lack of uniformity in the definition of treatment resistant depression (TRD)
within the Asia-Pacific (APAC) region may have implications for patient management. We …

[HTML][HTML] Pharmacologic approaches to treatment resistant depression: evidences and personal experience

A Tundo, R de Filippis, L Proietti - World journal of psychiatry, 2015 - ncbi.nlm.nih.gov
AIM: To review evidence supporting pharmacological treatments for treatment-resistant
depression (TRD) and to discuss them according to personal clinical experience …

Challenging treatment-resistant major depressive disorder: a roadmap for improved therapeutics

RT de Sousa, MV Zanetti, AR Brunoni… - Current …, 2015 - ingentaconnect.com
Major depressive disorder (MDD) is associated with a significant burden and costs to the
society. As remission of depressive symptoms is achieved in only one-third of the MDD …

Current and common definitions of treatment-resistant depression: findings from a systematic review and qualitative interviews

S Brown, K Rittenbach, S Cheung… - The Canadian …, 2019 - journals.sagepub.com
Objective: No universal definition for treatment-resistant depression (TRD) exists. This lack
of consensus reduces the generalizability of study findings and limits the ability to study …