BACKGROUND: Early identification of depressed individuals at high risk for treatment
resistance could be helpful in selecting optimal setting and intensity of care. At present …

Switching Antidepressant Class Does Not Improve Response or... : Journal of Clinical
Psychopharmacology Switching Antidepressant Class Does Not Improve Response or …

Objective: To summarize remission rates and dropouts due to adverse drug reactions
(ADRs) or lack of efficacy (LoE) of serotonin-norepinephrine reuptake inhibitors (SNRIs) …

The low rate of response to antidepressants in treatment resistant depression (TRD) justifies
studies of next‐step therapies following a treatment failure. In TRD clinical trials, it is …

Objective: Recommendations for treatment of chronic major depressive disorder (cMDD) are
mostly based on clinical experiences and on the literature on treatment-resistant depression …

Objective: To comparatively analyze the efficacy, acceptability, and tolerability of various
augmentation agents in adult patients with treatment-resistant depression. Data Sources: An …

Over a third of patients with major depressive disorder (MDD) do not have an adequate
response to first-line antidepressant treatments, ie, they have treatment-resistant depression …

Major Depressive Disorder (MDD) is a highly prevalent psychiatric disorder worldwide. It
causes individual suffering, loss of productivity, increased health care costs and high suicide …

Major depression does not always remit. Difficult‐to‐treat depression is thought to contribute
to the large disease burden posed by depression. Treatment‐resistant depression (TRD) is …

Background: Results from randomized controlled trials (RCTs) are considered to give the
most reliable information on treatment outcome (efficacy). Yet, the generalizability of efficacy …