Background: Pulmonary cell cultures are increasingly used to predict in vivo drug absorption
after inhalation, similar to intestinal cell culture models that have already been well …

Oral delivery is the most common mode of systemic drug application. Inhalation is mainly
used for local therapy of lung diseases but may also be a promising route for systemic …

Over recent years the research focus within the field of respiratory drug delivery has
broadened to include a wide range of potential applications for inhalation by delivering …

Delivery of therapeutic agents via the pulmonary route has gained significant attention over
the past few decades because this route of administration offers multiple advantages over …

Absorption studies with aerosol formulation delivered by metered dose inhalers across cell-
and tissue-based in vitro models of the pulmonary epithelia are not trivial due to the …

Mucus is widely disseminated in the nasal cavity, oral cavity, respiratory tract, eyes,
gastrointestinal tract, and reproductive tract to prevent the invasion of pathogenic bacteria …

Mucociliary clearance (MC), designed by evolution to eliminate inhaled and possibly
noxious material from the airways, considerably limits the benefit of inhalation therapy …

The mucus barrier is well established as a formidable barrier to exogenous substances and
forms the first line of defense for mucosal surfaces. Drugs and particle systems are known to …

The paper by HOHLFELD et al.[1] in this issue shows that, in rats, bronchoconstriction due to
inhaled acetylcholine is inhibited by inhaled aerosols of surfactant. Bronchoconstriction was …

This article reviews the state-of-the-art for in vitro experimental modelling involving the
deposition of respirable particles onto respiratory epithelial cells for the purpose of studying …