Mass transfer of deposited drug particles in the human lungs is an important factor in the
effective drug delivery by inhalation. This study is focused on the basic research related to …

Mucus is secreted within the respiratory tract down to the terminal bronchioles by the
combined activity of the epithelial goblet cells and submucosal mucous glands. These latter …

The main purpose of this work was to develop an in vitro method for simulating the
dissolution and absorption of inhaled dry powder drugs that also mimics systemic …

The small volume of airway lining fluid renders it susceptible to alteration by the deposition
of inhaled formulations. The increasing popularity of the pulmonary route for drug delivery …

The study focuses on the application of a cell integrated modified Andersen Cascade
Impactor (ACI) as an in vitro lung model for the evaluation of aerosols' behaviour of different …

No Heading Purpose. In this study, the suitability of the upper airway models, obtained by
applying a magnetic resonance imaging method, in simulating in vivo aerosol deposition …

A physiologically pertinent in vitro model is urgently needed for probing interactions
between inhaled drugs and the organic cation transporters (OCT) in the bronchial …

Purpose: The objective of this study was to develop a computational fluid dynamics (CFD)
model to predict the deposition, dissolution, clearance, and absorption of pharmaceutical …

Inhalation drug delivery is superior for local lung disease therapy. However, there are
several unique absorption barriers for inhaled drugs to overcome, including limited drug …

Mucosal drug delivery accounts for various administration routes (ie, oral, vaginal, ocular,
pulmonary, etc.) and offers a vast surface for the permeation of drugs. However, the mucus …