This report describes a novel technique for delivering aerosols to the surface of respiratory
epithelial cells cultured tit an air-liquid interface. A model microsphere formulation for nasal …

Purpose. The aim of this study was to characterize the permeability kinetics of salbutamol
sulfate, a commonly used β 2-agonist in the treatment of asthma exacerbation, across Calu …

Background: Although standard protocols for the study of drug delivery in the upper airways
using the sub-bronchial epithelial cell line Calu-3 model, particularly that of the air-liquid …

Pulmonary drug delivery represents an attractive, non-invasive administration option. In
addition to locally acting drugs, molecules that are intended to produce systemic effects can …

This study aims to systematically isolate different anatomical features of the human pharynx
with the goal to investigate their independent influence on airflow dynamics and particle …

Modulating and optimizing the local pharmacokinetics of inhaled drugs by chemical design
or formulation is challenged by the lack of predictive in vitro systems and in vivo techniques …

Importance of the field: Successful respiratory drug delivery for local and systemic purposes
is predicated on the availability of in vitro and in vivo methods for determining drug delivery …

The challenge of defining the concentration of unbound drug at the lung target site after
inhalation limits the possibility to optimize target exposure by compound design. In this …

Accumulation of respiratory drugs in human alveolar macrophages (AMs) has not been
extensively studied in vitro and in silico despite its potential impact on therapeutic efficacy …

The large epithelial surface area, the high organ vascularization, the thin nature of the
alveolar epithelium and the immense capacity for solute exchange are factors that led the …