Pulmonary dissolution of poorly soluble drug substances (DSs) may limit the drug
absorption rate and consequently influence clinical performance. Dissolution rate is thus an …

The unique physiology of the lungs necessitates special considerations for developing a
robust and discriminate dissolution method for orally inhaled drug products (OIDPs). Despite …

In vitro dissolution testing is routinely used in the development of pharmaceutical products.
Whilst the dissolution testing methods are well established and standardized for oral dosage …

Inhalation is the preferred route for the treatment of lung diseases. More recently, also
formulations for systemic treatment have been developed. For efficient development of …

Dissolution testing is routinely used for quality control purposes to test batch‐to‐batch
consistency, stability and detect manufacturing deviations of pharmaceutical products. While …

The main purpose of this work was to develop an in vitro method for simulating the
dissolution and absorption of inhaled dry powder drugs that also mimics systemic …

The aim of this research was to investigate a potential standardized test method to
characterize the dissolution properties of formulations intended for pulmonary delivery. A …

Almost all current orally inhaled drug products (OIDPs) are for the treatment of respiratory
diseases, and many have been designed using molecular or formulation strategies to retain …

Purpose To evaluate different dissolution testing methods and subsequently develop a
simple to perform but reproducible and discriminating dissolution technique for inhalative …

The dissolution of inhaled drug particles in the lungs is a challenge to model using
biorelevant methods in terms of (i) collecting a respirable emitted aerosol fraction and …