Heart disease is a common manifestation in conditions of iron imbalance. Normal heart
function requires coupling of iron supply for oxidative phosphorylation and redox signalling …

Iron is subject to tight homeostatic control in mammals. At the systemic level, iron
homeostasis is controlled by the liver-derived hormone hepcidin acting on its target …

Iron is a key micronutrient for the human body and participates in biological processes, such
as oxygen transport, storage, and utilization. Iron homeostasis plays a crucial role in the …

Iron deficiency is the most common nutritional disorder in the world. It is prevalent amongst
patients with cardiovascular disease, in whom it is associated with worse clinical outcomes …

Iron is an essential trace element required for several vital physiological and developmental
processes, including erythropoiesis, bone, and neuronal development. Iron metabolism and …

Highly active cardiomyocytes need iron for their metabolic activity. In physiological
conditions, iron turnover is a delicate process which is dependent on global iron supply and …

Hepcidin is the master regulator of systemic iron homeostasis. Derived primarily from the
liver, it inhibits the iron exporter ferroportin in the gut and spleen, the sites of iron absorption …

Iron is necessary for the life of practically all living things, yet it may also harm people
toxically. Accordingly, humans and other mammals have evolved an effective and tightly …

Major physiological functions of iron include oxygen transport as a component of
haemoglobin in blood (and myoglobin in striated muscle), energy production through …

Aims Iron deficiency (ID) is associated with adverse outcomes in heart failure (HF) but the
underlying mechanisms are incompletely understood. Intracellular iron availability is …