Chronic heart failure (HF) is often accompanied by systemic iron deficiency (ID). However,
effects of ID on cardiac iron status and progression of HF are unknown. To investigate these …

Iron plays a key pathophysiological role in a number of cardiac diseases. Studies on the
mechanisms of heart iron homeostasis are therefore crucial for understanding the causes of …

Iron deficiency is an extremely common comorbidity in patients with heart failure, affecting
up to 50% of all ambulatory patients. It is associated with reduced exercise capacity and …

Iron is needed for oxygen transport, muscle activity, mitochondrial function, DNA synthesis,
and sensing of hypoxia. The hierarchical master determinant of dietary iron absorption and …

This Focus Issue on heart failure (HF) and cardiomyopathies contains the State of the Art
Review article entitled 'Iron deficiency and cardiovascular disease'by Gianluigi Savarese …

The liver is the organ for iron storage and regulation; it senses circulating iron
concentrations in the body through the BMP‐SMAD pathway and regulates the iron intake …

Purpose of review To describe the role of iron deficiency in both heart failure and pulmonary
hypertension. Recent findings To role of iron deficiency in heart failure is well established …

The redox state of the cell is predominantly dependent on an iron redox couple and is
maintained within strict physiological limits. Iron is an essential metal for hemoglobin …

Anemia is common in patients with chronic kidney disease (CKD) and results from the
dysregulation of iron metabolism and erythropoiesis. Hepcidin is a key regulator of iron …

Iron deficiency and heart failure frequently co-occur, sparking clinical research into the role
of iron repletion in this condition over the last 20 years. Although early nonrandomized …