The geminin protein is a critical regulator of DNA replication. It functions to control replication
fidelity by blocking the assembly of prereplication complexes in the S and G 2 phases of the …

Geminin is an unstable regulatory protein that affects both cell division and cell
differentiation. Geminin inhibits a second round of DNA synthesis during S and G 2 phase by …

Eukaryotes have evolved multiple mechanisms to restrict DNA replication to once per cell
cycle. These mechanisms prevent relicensing of origins of replication after initiation of DNA …

Geminin is a multifunctional protein. After DNA replication is initiated during a cell cycle,
geminin binds to Cdt1, one of the key DNA replication licensing factors. This highly …

To maintain a stable genome, it is essential that replication origins fire only once per cell
cycle. The protein Geminin is thought to prevent a second round of DNA replication by …

A domain-specific disruption was performed on the destruction box sequence of
endogenous Geminin gene, an inhibitor of the DNA replication initiation complex, in a …

The origin licensing repressor geminin is a unique bifunctional protein providing a molecular
link between cellular proliferation, differentiation and genomic stability. Here we report the …

Geminin is a dual-function protein unique to multicellular animals with roles in modulating
gene expression and preventing DNA re-replication. Here, we show that geminin is …

Geminin is believed to have a major function in the regulation of genome replication and cell
proliferation. Published evidence shows that geminin specifically interacts with Cdt1 to block …

Cancers can be categorized into two groups: those whose frequency increases with age,
and those resulting from errors during mammalian development. The first group is linked to …