AIM: To review evidence supporting pharmacological treatments for treatment-resistant
depression (TRD) and to discuss them according to personal clinical experience …

When an antidepressant fails to help a depressed patient, clinicians are faced with the
daunting task of choosing the next treatment. Several pharmacologic and nonpharmacologic …

Therapy-resistant depression is not untreatable. Numerous treatment methods with
substantiated effectiveness exist. However, none of them are able to ensure remission …

BACKGROUND: Two broad treatment options exist for switching antidepressants for
depressed patients who fail to respond to a selective serotonin reuptake inhibitor (SSRI) …

Major depressive disorder is a frequent, serious disorder that usually responds partially to
treatment and leaves many patients with treatment resistance. This article reviews and …

Treatment-resistant depression (TRD) is a common clinical occurrence among patients
treated for major depressive disorder. However, a clear consensus regarding the criteria …

Importance of the field: Treatment-resistant depression (TRD) is common and debilitating.
Initial treatment is often insufficient to achieve full remission in a given depressive episode …

Background Patients with major depression respond to antidepressant treatment, but 10%–
30% of them do not improve or show a partial response coupled with functional impairment …

Treatment-resistant depression (TRD) presents many challenges for both patients and
physicians. This review aims to evaluate the current status of the field of TRD and reflects the …

Abstract Treatment-resistant depression (TRD) is a subset of Major Depressive Disorder
which does not respond to traditional and first-line therapeutic options. There are several …