Background Antidepressants are a first‐line treatment for adults with moderate to severe
major depression. However, many people prescribed antidepressants for depression don't …

The management of patients with depression who have failed to respond to antidepressant
medication is a common problem in general and old age psychiatry. It has been estimated …

OBJECTIVE: To summarize and discuss the conceptual and operational definitions of
treatment resistant/refractory depression (TRD) by systematically reviewing randomized …

Treatment-resistant depression (TRD) is a major public health problem in terms of its
prevalence and in terms of individual suffering and cost to society. Best estimates indicate …

Background: Major depressive disorder is a prevalent and disabling illness. Notwithstanding
numerous advances in the pharmacological treatment of depression, approximately 70% of …

Abstract Treatment-resistant depression (TRD) presents major challenges for both patients
and clinicians. There is no universally accepted definition of TRD, but results from the US …

Introduction: The authors describe the medications for treatment-resistant depression (TRD)
in phase II/III of clinical development in the EU and USA and provide an opinion on how …

Major depressive disorder (MDD) is associated with a significant burden and costs to the
society. As remission of depressive symptoms is achieved in only one-third of the MDD …

A wide variety of definitions are used for Treatment Resistant Depression (TRD), considering
various criteria and different concepts. Some of the key issues are: the diagnosis, the …

Major depressive disorder is a debilitating disease that imposes significant social and
economic burdens not only on patients but also on society. Although various treatment …