The effectiveness of treatments for depression is suboptimal for a significant portion of
individuals diagnosed with depressive illnesses. 1 At least 20% do not respond satisfactorily …

Bschor T, Baethge C. No evidence for switching the antidepressant: systematic review and
meta‐analysis of RCTs of a common therapeutic strategy. Objective: Switching …

The phenomenon of treatment-resistant depression (TRD), described as the occurrence of
an inadequate response after an adequate treatment with antidepressant agents (in terms of …

Our ability to treat depression has improved with the availability of receptor-specific and
chemically diverse groups of antidepressants. Even now, most of the short-term studies …

BACKGROUND: Treatment-resistant depression (TRD) is relatively common and accounts
for a large proportion of the overall burden caused by depression. We conducted a …

Abstract Treatment-resistant depression refers to major depressive disorder, treatment of the
disorder, and failure to obtain an “acceptable” outcome. Regarding the disorder, the …

Limitations by JOHN P. O'REARDON, MD; and JAY D. AMSTERDAM, MD lthough the
therapeutic armament-arium available for the clinician treating major depression has …

Switching Antidepressant Class Does Not Improve Response or... : Journal of Clinical
Psychopharmacology Switching Antidepressant Class Does Not Improve Response or …

Further research is needed to help improve both the standard of care and the outcome for
patients with treatment-resistant depression. A particularly critical evidence gap exists with …

A significant proportion of patients with major depressive disorder (MDD) fail to achieve
remission with standard antidepressant therapies, even when optimally delivered. These …