Despite the large number of depressed patients who do not respond to first-line
antidepressants, the evidence base of alternate strategies is quite thin. In this article, a …

Background Most adults with major depressive disorder (MDD) fail to achieve remission with
index pharmacological treatment. Moreover, at least half will not achieve and sustain …

Background Treatment resistant depression (TRD) characterizes a subgroup of 10–30% of
patients with major depressive disorder, and is associated with considerable morbidity and …

Over a third of patients with major depressive disorder (MDD) do not have an adequate
response to first-line antidepressant treatments, ie, they have treatment-resistant depression …

Background Varying conceptualizations of treatment‐resistant depression (TRD) have made
translating research findings or systematic reviews into clinical practice guidelines …

Background Clear guidance for successive antidepressant pharmacological treatments for
non-responders in major depression is not well established. Method Based on the …

Patients with major depressive disorder (MDD) often exhibit an inadequate treatment
response or failure to achieve remission following treatment with antidepressant drugs …

Despite substantial advances in treatment and management strategies for major depression,
less than 50% of patients respond to first-line antidepressant treatment or psychotherapy …

Sažetak Guidelines for the management of treatment-resistant depression (TRD) do not
meet the criteria of evidence-based medicine and better-quality research is required to …

Although antidepressants have helped millions worldwide, a substantial proportion of
patients fail to respond or remit. There is little published information available to clinicians for …