Objective: No universal definition for treatment-resistant depression (TRD) exists. This lack
of consensus reduces the generalizability of study findings and limits the ability to study …

A substantial proportion of depressed patients show only partial or no response to
antidepressants, and even among responders to antidepressant treatment, residual …

Depression is commonly diagnosed and treated in primary care. Recent evidence indicates
that the majority of depressed patients will not fully recover with an initial antidepressant …

Objective: Up to 15% of depression patients eventually present with treatment-resistant or
refractory depression (TRD), a condition that causes significant social and economic …

OBJECTIVE: This article reviews the concept of difficult-to-treat depression and outlines
some principles of pharmacologic management. METHODS: The authors conducted a …

Treatment resistant depression (TRD) is a serious public health problem. It is estimated that
around 20-40% of patients with a major depressive episode (whether monopolar or bipolar) …

Background The lack of uniformity in the definition of treatment resistant depression (TRD)
within the Asia-Pacific (APAC) region may have implications for patient management. We …

To compare the efficacy and tolerability of antidepressants switch with extended-release
venlafaxine (venlafaxine-XR), mirtazapine, and paroxetine in Chinese patients with major …

Effective pharmacological management of depression resistant to antidepressant
medication is best carried out in the context of a supportive and collaborative relationship …

One in three adults with major depressive disorder (MDD) do not experience clinically
significant improvement after multiple sequential courses of antidepressants and have …