OBJECTIVE To examine the utility of psychotherapy in managing treatment resistant
depression. DATA SOURCES PubMed, PsycInfo, Embase, Cochrane Registry of Controlled …

Despite the multitude of agents approved for the treatment of major depressive disorder,
approximately 50% of patients experience no response to treatment with a first-line …

Objective To compare the efficacy and discontinuation of augmentation agents in adult
patients with treatment-resistant depression (TRD). We conducted a systematic review and …

INTRODUCTION: For patients who continue to experience depressive symptoms despite an
adequate antidepressant SSRI trial, across-class switch is considered one of the best …

The term treatment-resistant depression (TRD) is widely used in the context of managing
mood disorders, but defining it, both conceptually and in practice, has proven difficult. Most …

Serotonin specific reuptake inhibitor antidepressants (SSRIs) have become the de facto first
line treatment in pharmacotherapy of major depression. Albeit SSRIs have the advantage in …

Background Treatment-resistant depression (TRD) is considered a common clinical
condition often associated with relevant suicidal ideation and characterized by a severe …

Background: Major depressive disorder (MDD) is a highly burdensome health condition, for
which there are numerous accepted pharmacological and psychological interventions …

Background. The failure to achieve remission for patients with Major Depressive Disorder
(MDD) represents a major public health concern. Inadequately treated depression is …

A significant proportion of depressed patients eventually present with treatment‐
resistant/refractory major depression (TRD), a debilitating condition that imposes significant …