Background Although antidepressants are often a first‐line treatment for adults with
moderate to severe depression, many people do not respond adequately to medication, and …

Objective: Many patients with depression remain poorly responsive to antidepressant
monotherapy. One approach for managing treatment-resistant depression is to combine …

Objective: A systematic review of all studies (controlled and uncontrolled) to evaluate
psychological interventions with treatment‐resistant depression. Method: A systematic …

The use of psychostimulants as an adjuvant therapy in treatment-resistant depression is not
very common nowadays and has been the subject of much criticism. This article gives a brief …

Background Whether olanzapine/fluoxetine combination (OFC) is superior to olanzapine or
fluoxetine monotherapy in patients with treatment-resistant depression (TRD) remains …

The concept of treatment-resistant or treatment-refractory depression (TRD) has evolved
over 40 years since the recognition that some patients minimally benefit from repeated …

As many as 30% of depressed patients fail to respond to treatment with an antidepressant
and at least 60% to 75% may fail to achieve complete remission. 57 In its broadest form …

Full symptomatic remission is the optimal outcome for patients with major depression.
Unfortunately, initial antidepressant efficacy is limited to partial response for many patients …

Treatment‐resistant depression (TRD) is common and associated with multiple serious
public health implications. A consensus definition of TRD with demonstrated predictive utility …

Major depressive disorder is a common and disabling illness that leads to significant
reductions in quality of life and considerable cost to society. Despite numerous advances in …