In the evaluation of treatment‐resistant or treatment‐refractory depression (TRD), true
resistance to antidepressant therapy must be distinguished from inadequate dose, duration …

Depression is a potentially life-threatening disorder affecting millions of people across the
globe. It is a huge burden to both the individual and society, costing over£ 9 billion in 2000 …

Objective: There are limited data comparing medication strategies in patients with
treatmentresistant depression. In this study, we compared the effects of combining …

Introduction Depression is a serious and widespread mental health disorder. Although
effective treatment does exist, a significant proportion of patients with depression fail to …

Objectives. Evidence in favour of switching between selective serotonin reuptake inhibitor
(SSRI) and tricyclic (TCA) antidepressants in treatment resistant depression has been tested …

It is generally accepted that as many as 30% of depressed patients fail to respond to
treatment with standard antidepressive pharmacotherapy. Surveys have revealed that as …

1. Major depressive disorder and treatment-resistant depression. 1.1. Major depressive
disorder. 1.2. Treatment-resistant depression (TRD). 1.3. Demographic and clinical risk …

The good news is that advances in the treatment of depression in the past decade have led
to better recognition of those with depression, and also to a reduction in the number of …

The goals of antidepressant treatment are to induce remission and prevent relapse or
recurrence. While response is the standard criterion applied to comparisons of …

Abstract Findings from the National Institute of Mental Health's Sequenced Treatment
Alternatives to Relieve Depression trial indicate that approximately 50% of patients with …