Purpose The ability of two semi-mechanistic simulation approaches to predict the systemic
pharmacokinetics (PK) of inhaled corticosteroids (ICSs) delivered via dry powder inhalers …

Purpose A combined in vitro–in silico methodology was designed to estimate
pharmacokinetics of budesonide delivered via dry powder inhaler. Methods Particle size …

In vitro dissolution testing is routinely used in the development of pharmaceutical products.
Whilst the dissolution testing methods are well established and standardized for oral dosage …

The main purpose of this work was to develop an in vitro method for simulating the
dissolution and absorption of inhaled dry powder drugs that also mimics systemic …

Dry powder inhalation therapy has been effective in treating localized lung diseases such
asthma, chronic obstructive pulmonary diseases (COPD), cystic fibrosis and lung infections …

The aim of this study was to reveal the relationship between human inspiratory flow patterns
and the concomitant drops in pressure in different inhalation devices, and the influence of …

Dry powder inhalers (DPIs) are used to deliver locally acting drugs (eg, bronchodilators and
corticosteroids) for treatment of lung diseases such as asthma and chronic obstructive …

The pulmonary route of administration is used for both locally and systemically acting drugs.
However, knowledge gaps about the fate of aerosol particles after deposition in the lung …

Inhalation is the preferred route for the treatment of lung diseases. More recently, also
formulations for systemic treatment have been developed. For efficient development of …

It has long been desired to match airflow conditions during formulation evaluation to those of
relevance to lung deposition. In this context several strategies have been adopted involving …