BACKGROUND: Two broad treatment options exist for switching antidepressants for
depressed patients who fail to respond to a selective serotonin reuptake inhibitor (SSRI) …

AIM: To review evidence supporting pharmacological treatments for treatment-resistant
depression (TRD) and to discuss them according to personal clinical experience …

Objective: Selective serotonin reuptake inhibitors (SSRIs) are frequently used as a first
antidepressant for major depressive disorder but have response rates of 50% to 60% in …

Bschor T, Baethge C. No evidence for switching the antidepressant: systematic review and
meta‐analysis of RCTs of a common therapeutic strategy. Objective: Switching …

Approximately 29% to 46% of depressed patients show only partial or no response to
treatment with antidepressants, with intolerance a frequent cause of treatment failure or …

Background: Many patients treated for major depression require more than one
antidepressant trial to achieve or sustain response. However, the literature provides few …

Background After unsuccessful treatment for depression with a selective serotonin-reuptake
inhibitor (SSRI), it is not known whether switching to one antidepressant is more effective …

Switching Antidepressant Class Does Not Improve Response or... : Journal of Clinical
Psychopharmacology Switching Antidepressant Class Does Not Improve Response or …

Selective serotonin reuptake inhibitors (SSRIs) are the most commonly prescribed class of
antidepressant (1) and are recommended as one of the first-line treatments (2–4) for major …

Background Although various strategies have been proposed to treat antidepressant
nonresponders, little controlled research has been published that examines prospectively …