[HTML][HTML] Pulmonary drug delivery

PCL Kwok, HK Chan - Therapeutic delivery, 2013 - Taylor & Francis
Ther. Deliv.(2013) 4 (8) 878 future science group these affected the in vitro aerosol
performance of the powders. In the special report, Smutney and Grant discuss various …

Influence of peak inspiratory flow rates and pressure drops on inhalation performance of dry powder inhalers

D Hira, T Okuda, M Ichihashi, A Mizutani… - Chemical and …, 2012 - jstage.jst.go.jp
The aim of this study was to reveal the relationship between human inspiratory flow patterns
and the concomitant drops in pressure in different inhalation devices, and the influence of …

[HTML][HTML] In Vitro to ex Vivo/In Vivo Correlation (IVIVC) of dissolution kinetics from inhaled particulate solutes using air/blood barrier models: Relation between in vitro …

P Gerde, M Malmlöf, E Selg - Journal of Aerosol Science, 2021 - Elsevier
Correlating data from in vitro dissolution testing of inhaled particulate pharmaceuticals or air
pollutants with the dissolution and distribution to the blood circulation of the same aerosols …

[HTML][HTML] Drug Absorption Parameters Obtained Using the Isolated Perfused Rat Lung Model Are Predictive of Rat In Vivo Lung Absorption

J Eriksson, E Sjögren, H Lennernäs, H Thörn - The AAPS Journal, 2020 - Springer
The ex vivo isolated perfused rat lung (IPL) model has been demonstrated to be a useful tool
during drug development for studying pulmonary drug absorption. This study aims to …

[HTML][HTML] Characterization and formulation of isoniazid for high-dose dry powder inhalation

I Sibum, P Hagedoorn, HW Frijlink, F Grasmeijer - Pharmaceutics, 2019 - mdpi.com
Tuberculosis is a major health problem and remains one of the main causes of mortality. In
recent years, there has been an increased interest in the pulmonary delivery of antibiotics to …

Influence of formulation excipients and physical characteristics of inhalation dry powders on their aerosolization performance

C Bosquillon, C Lombry, V Preat, R Vanbever - Journal of controlled release, 2001 - Elsevier
The objective of this study was to determine the effects of formulation excipients and
physical characteristics of inhalation particles on their in vitro aerosolization performance …

Dose delivery late in the breath can increase dry powder aerosol penetration into the lungs

E Bondesson, T Bengtsson, L Borgström… - Journal of aerosol …, 2005 - liebertpub.com
In addition to aerosol particle size and mode of inhalation, the time-point of dose delivery
during inhalation may be an important factor governing the intrapulmonary distribution of …

Nicotine microaerosol inhaler

PG Andrus, R Rhem, J Rosenfeld… - Canadian respiratory …, 1999 - Wiley Online Library
OBJECTIVE: To measure the droplet size distribution of a nicotine pressurized metered‐
dose inhaler using a nicotine in ethanol solution formulation with hydrofluoroalkane as …

[图书][B] Creation and validation of an enhanced in vitro model of the lung

SR Gharse - 2012 - search.proquest.com
The increasing prominence of pulmonary drug delivery for local and systemic treatments
coupled with the complex lung structure and the numerous factors affecting the pulmonary …

Modeling of Inhalation Profiles Through Dry Powder Inhaler in Healthy Adults and Asthma Patients As a Prerequisite for Further In Vitro and In Silico Studies

A Dorosz, T Urbankowski, K Zieliński… - Journal of Aerosol …, 2022 - liebertpub.com
Background: The severity of airway obstruction may affect patient's ability to perform an
effective drug inhalation from a dry powder inhaler (DPI). Also, an incorrect inhalation …