Influence of peak inspiratory flow rates and pressure drops on inhalation performance of dry powder inhalers
D Hira, T Okuda, M Ichihashi, A Mizutani… - Chemical and …, 2012 - jstage.jst.go.jp
The aim of this study was to reveal the relationship between human inspiratory flow patterns
and the concomitant drops in pressure in different inhalation devices, and the influence of …
and the concomitant drops in pressure in different inhalation devices, and the influence of …
[HTML][HTML] In Vitro to ex Vivo/In Vivo Correlation (IVIVC) of dissolution kinetics from inhaled particulate solutes using air/blood barrier models: Relation between in vitro …
P Gerde, M Malmlöf, E Selg - Journal of Aerosol Science, 2021 - Elsevier
Correlating data from in vitro dissolution testing of inhaled particulate pharmaceuticals or air
pollutants with the dissolution and distribution to the blood circulation of the same aerosols …
pollutants with the dissolution and distribution to the blood circulation of the same aerosols …
[HTML][HTML] Drug Absorption Parameters Obtained Using the Isolated Perfused Rat Lung Model Are Predictive of Rat In Vivo Lung Absorption
The ex vivo isolated perfused rat lung (IPL) model has been demonstrated to be a useful tool
during drug development for studying pulmonary drug absorption. This study aims to …
during drug development for studying pulmonary drug absorption. This study aims to …
[HTML][HTML] Characterization and formulation of isoniazid for high-dose dry powder inhalation
I Sibum, P Hagedoorn, HW Frijlink, F Grasmeijer - Pharmaceutics, 2019 - mdpi.com
Tuberculosis is a major health problem and remains one of the main causes of mortality. In
recent years, there has been an increased interest in the pulmonary delivery of antibiotics to …
recent years, there has been an increased interest in the pulmonary delivery of antibiotics to …
Influence of formulation excipients and physical characteristics of inhalation dry powders on their aerosolization performance
C Bosquillon, C Lombry, V Preat, R Vanbever - Journal of controlled release, 2001 - Elsevier
The objective of this study was to determine the effects of formulation excipients and
physical characteristics of inhalation particles on their in vitro aerosolization performance …
physical characteristics of inhalation particles on their in vitro aerosolization performance …
Dose delivery late in the breath can increase dry powder aerosol penetration into the lungs
E Bondesson, T Bengtsson, L Borgström… - Journal of aerosol …, 2005 - liebertpub.com
In addition to aerosol particle size and mode of inhalation, the time-point of dose delivery
during inhalation may be an important factor governing the intrapulmonary distribution of …
during inhalation may be an important factor governing the intrapulmonary distribution of …
Nicotine microaerosol inhaler
PG Andrus, R Rhem, J Rosenfeld… - Canadian respiratory …, 1999 - Wiley Online Library
OBJECTIVE: To measure the droplet size distribution of a nicotine pressurized metered‐
dose inhaler using a nicotine in ethanol solution formulation with hydrofluoroalkane as …
dose inhaler using a nicotine in ethanol solution formulation with hydrofluoroalkane as …
[图书][B] Creation and validation of an enhanced in vitro model of the lung
SR Gharse - 2012 - search.proquest.com
The increasing prominence of pulmonary drug delivery for local and systemic treatments
coupled with the complex lung structure and the numerous factors affecting the pulmonary …
coupled with the complex lung structure and the numerous factors affecting the pulmonary …
Modeling of Inhalation Profiles Through Dry Powder Inhaler in Healthy Adults and Asthma Patients As a Prerequisite for Further In Vitro and In Silico Studies
A Dorosz, T Urbankowski, K Zieliński… - Journal of Aerosol …, 2022 - liebertpub.com
Background: The severity of airway obstruction may affect patient's ability to perform an
effective drug inhalation from a dry powder inhaler (DPI). Also, an incorrect inhalation …
effective drug inhalation from a dry powder inhaler (DPI). Also, an incorrect inhalation …