Importance of the field: Treatment-resistant depression (TRD) is common and debilitating.
Initial treatment is often insufficient to achieve full remission in a given depressive episode …

A significant proportion of patients with major depressive disorder (MDD) fail to achieve
remission with standard antidepressant therapies, even when optimally delivered. These …

AIM: To review evidence supporting pharmacological treatments for treatment-resistant
depression (TRD) and to discuss them according to personal clinical experience …

Abstract Treatment-resistant depression (TRD) is a subset of Major Depressive Disorder
which does not respond to traditional and first-line therapeutic options. There are several …

Introduction: The authors describe the medications for treatment-resistant depression (TRD)
in phase II/III of clinical development in the EU and USA and provide an opinion on how …

When an antidepressant fails to help a depressed patient, clinicians are faced with the
daunting task of choosing the next treatment. Several pharmacologic and nonpharmacologic …

Treatment-resistant depression (TRD) presents many challenges for both patients and
physicians. This review aims to evaluate the current status of the field of TRD and reflects the …

Depressive disorders are a leading cause of disability worldwide and greatly impact
morbidity, health care utilization, and medical costs. Major depression that does not resolve …

Background. The failure to achieve remission for patients with Major Depressive Disorder
(MDD) represents a major public health concern. Inadequately treated depression is …

Despite the large number of depressed patients who do not respond to first-line
antidepressants, the evidence base of alternate strategies is quite thin. In this article, a …