Purpose The ability of two semi-mechanistic simulation approaches to predict the systemic
pharmacokinetics (PK) of inhaled corticosteroids (ICSs) delivered via dry powder inhalers …

In vitro dissolution testing is routinely used in the development of pharmaceutical products.
Whilst the dissolution testing methods are well established and standardized for oral dosage …

Background: Pulmonary drug delivery is an accepted route of drug administration for the
management of lung conditions and diseases as well as an evolving route of administration …

Almost all current orally inhaled drug products (OIDPs) are for the treatment of respiratory
diseases, and many have been designed using molecular or formulation strategies to retain …

Poorly water‐soluble drugs represent the major part of the current and future market. Drug
insolubility could impair the absorption through biological membranes and/or the …

The aim of this study was to further evaluate and optimize the Transwell® system for
assessing the dissolution behavior of orally inhaled drug products (OIDPs), using fluticasone …

Drug absorption is a complex process involving dissolution and precipitation, along with
other kinetic processes. The purpose of this work was to (1) establish an in vitro …

Traditionally, developing inhaled drug formulations relied on trial and error, yet recent
technological advancements have deepened the understanding of 'inhalation …

Abstract The Biopharmaceutics Classification System (BCS), developed in the 1990s for oral
immediate release drugs, is utilized by R&D scientists and regulators to streamline product …

The assessment and prediction of lung absorption and disposition are an increasingly
essential preclinical task for successful discovery and product development of inhaled drugs …