A series of poorly soluble BCS class II compounds with “grease ball” characteristics were
assessed for solubility and dissolution rate in biorelevant dissolution media (BDM) with the …

Although there is a modest body of literature on the absorption of inhaled pharmaceuticals
by normal lungs and some limited information from diseased lungs, there is still a surprising …

This study aims to assess the absorption potential of oral absorption of poorly water-soluble
drugs by using the dissolution/permeation system (D/P system). The D/P system can be …

The aim of the study was to develop a robust and standardized in vitro dissolution
methodology for orally inhaled drug products (OIDPs). An aerosol dose collection (ADC) …

Combined dissolution and permeation systems are designed to simultaneously assess the
dissolution of a pharmaceutical dosage form and the permeation of dissolved drugs …

The objective of present study is to develop pharmacokinetic (PK) prediction methods using
in silico PK model for oral immediate release drug products (ie solution, suspension, and …

Oral delivery is the most common mode of systemic drug application. Inhalation is mainly
used for local therapy of lung diseases but may also be a promising route for systemic …

Purpose To evaluate different dissolution testing methods and subsequently develop a
simple to perform but reproducible and discriminating dissolution technique for inhalative …

The aim of the present work was to confirm the usefulness of the dissolution/permeation
system (D/P system) in the estimation of human oral absorption of poorly water-soluble …

Drug product performance testing is an important part of quality-by-design approaches, but
this process often lacks the underlying mechanistic understanding of the complex …