Drug product performance testing is an important part of quality-by-design approaches, but
this process often lacks the underlying mechanistic understanding of the complex …

Incubation time plays a critical role in the accurate measurement of equilibrium solubility of
compounds. Substances which dissolve very slowly generally need long incubation times …

Prediction of local exposure following inhalation of a locally acting pulmonary drug is central
to the successful development of novel inhaled medicines, as well as generic equivalents …

Purpose For optimizing the local, pulmonary targeting of inhaled medications, it is important
to analyze the relationship between the physicochemical properties of small molecules and …

The dissolution of a drug administered in the solid state is a pre-requisite for efficient
subsequent transport within the human body. This is because only dissolved drug …

The dissolution of powder drugs, besides being a topic of utmost importance, especially for
the sparingly soluble ones, is far from being well-explained. The purpose of the present …

Over the past 20 years, the isolated perfused lung (IPL) technique has been developed for
the evaluation of pulmonary drug absorption and disposition. The procedure for establishing …

ABSTRACT A novel dissolution method was developed, suitable for powder mixtures, based
on the USP basket apparatus. The baskets were modified such that the powder mixtures …

Dissolution has become an indispensable tool to predict the in vivo performance of dosage
form, especially in recent times, because of the increasing complexity of new drugs …

In this review article, three different approaches to predict in vivo oral absorption based on
the in vitro data of drug permeability, solubility and dissolution were introduced. At the drug …