The portfolio of compounds approved for inhalation therapy has expanded rapidly for
treatment of lung diseases. To assess the efficacy and safety of inhaled medicines, a better …

The evolution of lung drug-delivery technology has undergone significant advances over the
last few decades, so that today it is one of the most effective and rapid modalities for treating …

Inhaled therapy confers key advantages for the treatment of topical pulmonary diseases and
offers potential for systemic delivery of medicines. Dry powder inhalers (DPIs) are generally …

The usefulness of selected biorelevant dissolution media (BDM) to predict in vivo drug
absorption was studied. Dissolution profiles of solid formulations of a poorly soluble model …

Dissolution models require, at their core, an accurate diffusion model. The accuracy of the
model for diffusion-dominated dissolution is particularly important with the trend toward …

Delivery of therapeutic agents via the pulmonary route has gained significant attention over
the past few decades because this route of administration offers multiple advantages over …

Weakly basic drugs exhibit a pH-dependent dissolution profile in the gastrointestinal (GI)
tract, which makes it difficult to predict their oral absorption profile. The aim of this study was …

Purpose. To quantitatively compare in vitro dissolution data in biorelevant and compendial
media, to investigate whether in vitro differences are reflected in the simulated plasma …

Introduction: The process of drug disposition in the lung after pulmonary delivery is complex
involving absorptive and non-absorptive mechanisms. The lung has also been suggested to …