Lung cancer is the most frequently diagnosed malignancy that contributes to high proportion
of deaths globally among patients who die due to cancer. Chemotherapy remains the …

Attempting to improve the anticancer activity and solubility of evodiamine in simulated
gastric fluid (SGF) and simulated intestinal fluid (SIF) solutions, thirty-eight N13-substituted …

Evodiamine (EVO), a natural dietary alkaloid extracted from the roots of the Evodia
rutaecarpa, has shown anticancer activities. Here, we have investigated EVO's role in …

Emodin is a cell arrest and apoptosis-inducing compound that is widely distributed in
different plants (rhubarb, aloe), lichens and terrestrial fungi, and also isolated from marine …

Hepatocellular cancer (HCC) is a lethal malignancy with poor prognosis and easy
recurrence. There are few agents with minor toxic side effects that can be used for treatment …

Chemo-resistance is the main factor for poor prognosis in human ovarian epithelial cancer.
Active constituents derived from Chinese medicine with anti-cancer potential might …

Emodin is a natural compound found in several traditional Chinese medicines, including
Rheum palmatum and Polygonum cuspidatum. Recent studies have shown that emodin …

Autophagy is a regulated lysosomal pathway involving the bulk degradation of cytoplasmic
contents, and is an emerging attractive therapeutic approach for treating cancers. In the …

Inspired by the natural product evodiamine, a novel antitumor indolopyrazinoquinazolinone
scaffold was designed by scaffold hopping. Structure–activity relationship studies led to the …

PURPOSE: Although evodiamine, an alkaloid isolated from Evodiae fructus, has been
reported to exert anticancer activities, to our knowledge its target and mechanism of action …