FGF-1 reverts epithelial-mesenchymal transition induced by TGF-β1 through MAPK/ERK kinase pathway

C Ramos, C Becerril, M Montaño… - … of Physiology-Lung …, 2010 - journals.physiology.org
Idiopathic pulmonary fibrosis (IPF) is a progressive and lethal lung disease characterized by
the expansion of the fibroblast/myofibroblast population and aberrant remodeling. However …

Inhibition of plasminogen activator inhibitor-1 attenuates transforming growth factor-β-dependent epithelial mesenchymal transition and differentiation of fibroblasts to …

K Omori, N Hattori, T Senoo, Y Takayama, T Masuda… - PloS one, 2016 - journals.plos.org
Transforming growth factor-β (TGF-β) is central during the pathogenesis of pulmonary
fibrosis, in which the plasminogen activator inhibitor-1 (PAI-1) also has an established role …

Pirfenidone modulates macrophage polarization and ameliorates radiation‐induced lung fibrosis by inhibiting the TGF‐β1/Smad3 pathway

H Ying, M Fang, QQ Hang, Y Chen… - Journal of cellular …, 2021 - Wiley Online Library
Radiation‐induced lung injury (RILI) mainly contributes to the complications of thoracic
radiotherapy. RILI can be divided into radiation pneumonia (RP) and radiation‐induced lung …

Use of animal models in IPF research

R Carrington, S Jordan, SC Pitchford… - Pulmonary pharmacology …, 2018 - Elsevier
Idiopathic pulmonary fibrosis (IPF) is a fatal interstitial lung disease with a poor prognosis
and limited treatment options. Many compounds have shown efficacy in preclinical models …

Idiopathic pulmonary fibrosis is associated with endothelial to mesenchymal transition

D Nataraj, A Ernst, R Kalluri - American journal of respiratory cell …, 2010 - atsjournals.org
Idiopathic pulmonary fibrosis (IPF) affects over 500,000 people in the United States and
Europe alone. The disease is characterized by progressive obliteration of normal alveolar …

Idiopathic pulmonary fibrosis and lung cancer: mechanisms and molecular targets

B Ballester, J Milara, J Cortijo - International journal of molecular sciences, 2019 - mdpi.com
Idiopathic pulmonary fibrosis (IPF) is the most common idiopathic interstitial pulmonary
disease with a median survival of 2–4 years after diagnosis. A significant number of IPF …

Efficacy of low dose pirfenidone in idiopathic pulmonary fibrosis: real world experience from a tertiary university hospital

MJ Song, SW Moon, JS Choi, SH Lee, SH Lee… - Scientific reports, 2020 - nature.com
Pirfenidone is an antifibrotic agent that has been proven to slow down the progression of
idiopathic pulmonary fibrosis (IPF). The aim of this study was to evaluate the efficacy of low …

Pathogenetic pathways and novel pharmacotherapeutic targets in idiopathic pulmonary fibrosis

KM Antoniou, A Pataka, D Bouros… - Pulmonary pharmacology …, 2007 - Elsevier
Idiopathic pulmonary fibrosis (IPF) is a poorly understood disease that usually leads to death
within 5 years of diagnosis. Despite our better understanding of IPF pathogenesis, the …

[PDF][PDF] Recent advances in idiopathic pulmonary fibrosis

S Park, EJ Lee - Tuberculosis and respiratory diseases, 2013 - synapse.koreamed.org
The concept on idiopathic pulmonary fibrosis (IPF) pathogenesis has progressed from
chronic inflammation to aberrant wounding healing and even more to the current paradigms …

Update on therapeutic management of idiopathic pulmonary fibrosis

A Tzouvelekis, F Bonella… - Therapeutics and clinical …, 2015 - Taylor & Francis
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive diffuse parenchymal lung
disease of unknown origin, with a mortality rate exceeding that of many cancers. The …