Purpose The ability of two semi-mechanistic simulation approaches to predict the systemic
pharmacokinetics (PK) of inhaled corticosteroids (ICSs) delivered via dry powder inhalers …

Inhalation is the preferred route for the treatment of lung diseases. More recently, also
formulations for systemic treatment have been developed. For efficient development of …

Since lung residence time depends on dissolution rate, dissolution testing could also help to
determine the likelihood of accumulation of drug in the lungs over time or whether a topical …

One of the simplest design concepts of inhaled sustained drug delivery to the lung is to
utilize the slow dissolution of drug crystals with poor aqueous solubility. An optimum …

Glucocorticoids administered by inhalation remain a first-line treatment of patients with
asthma allergic rhinitis and advanced chronic obstructive pulmonary disease. Budesonide …

Dissolution testing for inhalers were previously conducted either on unfractionated drug-
carrier powders or drug of specific aerodynamic particle size. In this study, the collection of …

CONCLUSIONS The DissolvIt system successfully differentiated between three compounds
with different physiochemical properties. In this study, differences in the rate of absorption …

The surface of lactose monohydrate was modified by solution phase variable temperature
dissolution. Lactose monohydrate crystals were added to a known volume of a saturated …