α-Hemolysin of uropathogenic E. coli regulates NLRP3 inflammasome activation and mitochondrial dysfunction in THP-1 macrophages

V Verma, P Kumar, S Gupta, S Yadav, RS Dhanda… - Scientific Reports, 2020 - nature.com
Hemolysin expressing UPEC strains have been associated with severe advanced kidney
pathologies, such as cystitis and pyelonephritis, which are associated with an inflammatory …

Variation in hemolysin A expression between uropathogenic Escherichia coli isolates determines NLRP3‐dependent vs. ‐independent macrophage cell death and …

AMV Murthy, MJ Sullivan, NTK Nhu, AW Lo… - The FASEB …, 2019 - Wiley Online Library
Uropathogenic Escherichia coli (UPEC) is the major cause of urinary tract infections (UTIs).
The multidrug‐resistant E. coli sequence type 131 (ST131) clone is a serious threat to …

Regulation of hemolysin in uropathogenic Escherichia coli fine-tunes killing of human macrophages

A MV Murthy, MD Phan, KM Peters, NTK Nhu… - Virulence, 2018 - Taylor & Francis
Uropathogenic E. coli (UPEC) causes the majority of urinary tract infections (UTIs), which are
a major global public health concern. UPEC uses numerous mechanisms to subvert the …

The UPEC pore-forming toxin α-hemolysin triggers proteolysis of host proteins to disrupt cell adhesion, inflammatory, and survival pathways

BK Dhakal, MA Mulvey - Cell host & microbe, 2012 - cell.com
Uropathogenic Escherichia coli (UPEC), which are the leading cause of both acute and
chronic urinary tract infections, often secrete a labile pore-forming toxin known as α …

Uropathogenic Escherichia coli virulence factor hemolysin A causes programmed cell necrosis by altering mitochondrial dynamics

Y Lu, A Rafiq, Z Zhang, F Aslani, M Fijak… - The FASEB …, 2018 - Wiley Online Library
Uropathogenic Escherichia coli (UPEC) is the most common cause of urinary tract infections.
In this study, UPEC strains harboring hemolysin A (HlyA) did not induce programmed cell …

Dysregulation of Escherichia coli α-hemolysin expression alters the course of acute and persistent urinary tract infection

K Nagamatsu, TJ Hannan, RL Guest… - Proceedings of the …, 2015 - National Acad Sciences
Urinary tract infections (UTIs) are among the most common bacterial infections, causing
considerable morbidity in females. Infection is highly recurrent despite appropriate antibiotic …

A previously uncharacterized two-component signaling system in uropathogenic Escherichia coli coordinates protection against host-derived oxidative stress with …

H Gu, X Cai, X Zhang, J Luo, X Zhang, X Hu… - PLoS …, 2021 - journals.plos.org
Uropathogenic Escherichia coli (UPEC) deploy an array of virulence factors to successfully
establish urinary tract infections. Hemolysin is a pore-forming toxin, and its expression …

Haemolysin Ahh1 secreted from Aeromonas dhakensis activates the NLRP3 inflammasome in macrophages and mediates severe soft tissue infection

YC Su, CC Wang, YW Chen, ST Wang, CY Shu… - International …, 2024 - Elsevier
Severe soft tissue infections caused by Aeromonas dhakensis, such as necrotizing fasciitis
or cellulitis, are prevalent in southern Taiwan and around the world. However, the …

[HTML][HTML] Lack of P2X7 Receptors Protects against Renal Fibrosis after Pyelonephritis with α-Hemolysin–Producing Escherichia coli

JR Therkildsen, MG Christensen, SJ Tingskov… - The American journal of …, 2019 - Elsevier
Severe urinary tract infections are commonly caused by sub-strains of Escherichia coli
secreting the pore-forming virulence factor α-hemolysin (HlyA). Repeated or severe cases of …

α-Hemolysin promotes uropathogenic E. coli persistence in bladder epithelial cells via abrogating bacteria-harboring lysosome acidification

M Naskar, VP Parekh, MA Abraham, Z Alibasic… - PLoS …, 2023 - journals.plos.org
There is a growing consensus that a significant proportion of recurrent urinary tract infections
are linked to the persistence of uropathogens within the urinary tract and their re-emergence …