Autophagy in human health and disease: novel therapeutic opportunities

F Giampieri, S Afrin, TY Forbes-Hernandez… - Antioxidants & redox …, 2019 - liebertpub.com
Significance: In eukaryotes, autophagy represents a highly evolutionary conserved process,
through which macromolecules and cytoplasmic material are degraded into lysosomes and …

Autophagy, cell death, and cancer

L Lin, EH Baehrecke - Molecular & cellular oncology, 2015 - Taylor & Francis
Autophagy is an evolutionarily conserved intracellular catabolic process that is used by all
cells to degrade dysfunctional or unnecessary cytoplasmic components through delivery to …

[HTML][HTML] The emerging roles of autophagy in human diseases

Y Lei, DJ Klionsky - Biomedicines, 2021 - mdpi.com
Autophagy, a process of cellular self-digestion, delivers intracellular components including
superfluous and dysfunctional proteins and organelles to the lysosome for degradation and …

Autophagy—cell survival and death

X Yan, R Zhou, Z Ma - Autophagy: Biology and Diseases: Basic Science, 2019 - Springer
Autophagy, which is one of the most important ways to maintain cell homeostasis plays an
important regulatory role in cell survival and death. Currently, it is agreed that autophagy …

[HTML][HTML] Autophagy, a guardian against neurodegeneration

M García-Arencibia, WE Hochfeld, PPC Toh… - Seminars in cell & …, 2010 - Elsevier
Autophagy is an intracellular degradation process responsible for the clearance of most long-
lived proteins and organelles. Cytoplasmic components are enclosed by double-membrane …

[HTML][HTML] Selective autophagy in cancer: mechanisms, therapeutic implications, and future perspectives

J Liu, Y Wu, S Meng, P Xu, S Li, Y Li, X Hu, L Ouyang… - Molecular cancer, 2024 - Springer
Eukaryotic cells engage in autophagy, an internal process of self-degradation through
lysosomes. Autophagy can be classified as selective or non-selective depending on the way …

Autophagy in health and disease. 1. Regulation and significance of autophagy: an overview

M Mehrpour, A Esclatine, I Beau… - American Journal of …, 2010 - journals.physiology.org
Macroautophagy is a vacuolar degradation pathway that terminates in the lysosomal
compartment after formation of a cytoplasmic vacuole or autophagosome that engulfs …

[HTML][HTML] Autophagy and disease

A Thorburn - Journal of biological chemistry, 2018 - ASBMB
As outlined in the accompanying Minireviews, autophagy is a complicated and highly
regulated process that delivers cellular material to lysosomes for degrading, recycling, and …

[HTML][HTML] Autophagy: Regulator of cell death

SZ Liu, SJ Yao, H Yang, SJ Liu, YJ Wang - Cell death & disease, 2023 - nature.com
Autophagy is the process by which cells degrade and recycle proteins and organelles to
maintain intracellular homeostasis. Generally, autophagy plays a protective role in cells, but …

Autophagy and cancer therapy

Y Kondo, S Kondo - Autophagy, 2006 - Taylor & Francis
Autophagy is a dynamic process of protein degradation which is typically observed during
nutrient deprivation. Recently, interest in autophagy has been renewed among oncologists …