Immune checkpoint inhibitor resistance in hepatocellular carcinoma

Z Wang, Y Wang, P Gao, J Ding - Cancer letters, 2023 - Elsevier
The application of immune checkpoint inhibitors (ICIs) has markedly enhanced the treatment
of hepatocellular carcinoma (HCC), and HCC patients who respond to ICIs have shown …

[HTML][HTML] Mechanisms of primary and acquired resistance to immune checkpoint inhibitors in patients with hepatocellular carcinoma

S De Lorenzo, F Tovoli, F Trevisani - Cancers, 2022 - mdpi.com
Simple Summary Immune checkpoint inhibitors (ICIs) are now a cornerstone of systemic
treatment for hepatocellular carcinoma (HCC). However, their efficacy is blunted by …

[HTML][HTML] Immune checkpoint inhibitors in hepatocellular cancer: current understanding on mechanisms of resistance and biomarkers of response to treatment

AE Onuma, H Zhang, H Huang, TM Williams… - Gene …, 2020 - ncbi.nlm.nih.gov
Hepatocellular carcinoma (HCC) is the most common primary liver malignancy worldwide
and a leading cause of death worldwide. Its incidence continues to increase in the US due to …

Immune checkpoint inhibitors in HCC: Cellular, molecular and systemic data

U Harkus, M Wankell, P Palamuthusingam… - Seminars in Cancer …, 2022 - Elsevier
Hepatocellular carcinoma (HCC) is one of the leading causes of cancer related deaths in the
world, and for patients with advanced disease there are few therapeutic options available …

Adverse effects of immune-checkpoint inhibitors in hepatocellular carcinoma

T Cui, Y Liu, J Wang, L Liu - OncoTargets and therapy, 2020 - Taylor & Francis
Immune-modulatory therapy, especially with immune-checkpoint inhibitors (ICIs), has
reshaped cancer therapeutics. Immunotherapy is relatively a novel approach that can …

[HTML][HTML] Immune checkpoint inhibitors in hepatocellular carcinoma: current progresses and challenges

HT Liu, MJ Jiang, ZJ Deng, L Li, JL Huang… - Frontiers in …, 2021 - frontiersin.org
Hepatocellular carcinoma (HCC) is one of the most common malignant tumor in the world
and its incidence is increasing in many countries. In recent years, with the deepening …

[HTML][HTML] Recent advances in immunotherapy for hepatocellular carcinoma

S Nakano, Y Eso, H Okada, A Takai, K Takahashi… - Cancers, 2020 - mdpi.com
Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related death since
most patients are diagnosed at advanced stage and the current systemic treatment options …

Immune checkpoint inhibitors for hepatocellular carcinoma

I El Dika, DN Khalil, GK Abou‐Alfa - Cancer, 2019 - Wiley Online Library
The position of immunotherapy as a pillar of systemic cancer treatment has been firmly
established over the past decade. Immune checkpoint inhibitors are a welcome option for …

[PDF][PDF] Immune checkpoint blockade in hepatocellular carcinoma: current progress and future directions

T Hato, L Goyal, TF Greten, DG Duda, AX Zhu - Hepatology, 2014 - Wiley Online Library
Immune checkpoint blockade has recently emerged as a promising therapeutic approach for
various malignancies including hepatocellular carcinoma (HCC). Preclinical and clinical …

[HTML][HTML] Biochemical predictors of response to immune checkpoint inhibitors in unresectable hepatocellular carcinoma

A Rizzo, G Brandi - Cancer treatment and research communications, 2021 - Elsevier
Hepatocellular carcinoma (HCC) represents the most commonly diagnosed liver cancer
worldwide, and the overall survival of patients with unresectable disease is poor. In the last …