Association of cardiovascular risk factors and lifestyle behaviors with hypertension: a mendelian randomization study

S van Oort, JWJ Beulens, AJ van Ballegooijen… - …, 2020 - Am Heart Assoc
Hypertension is a major risk factor for cardiovascular disease and mortality. To identify
targets for the prevention of hypertension and its associated disease burden, we used the 2 …

Relationship between blood pressure and incident cardiovascular disease: linear and nonlinear Mendelian randomization analyses

R Malik, MK Georgakis, M Vujkovic, SM Damrauer… - …, 2021 - Am Heart Assoc
Observational studies exploring whether there is a nonlinear effect of blood pressure on
cardiovascular disease (CVD) risk are hindered by confounding. This limitation can be …

Independent associations of education, intelligence, and cognition with hypertension and the mediating effects of Cardiometabolic risk factors: a Mendelian …

Y Wang, C Ye, L Kong, J Zheng, M Xu, Y Xu, M Li… - …, 2023 - Am Heart Assoc
Background: Education, intelligence, and cognition are associated with hypertension, but
which one plays the most prominent role in the pathogenesis of hypertension and which …

The environmental and genetic evidence for the association of hyperlipidemia and hypertension

Y Ruixing, W Jinzhen, L Weixiong, C Yuming… - Journal of …, 2009 - journals.lww.com
Objective Both hyperlipidemia and hypertension are the risk factors for coronary heart
disease. Although studies have shown that there is an association between plasma lipid and …

Blood pressure and risk of cardiovascular disease in UK biobank: a mendelian randomization study

EYF Wan, WT Fung, CM Schooling, SL Au Yeung… - …, 2021 - Am Heart Assoc
This study aims to evaluate the causal association of blood pressure (BP) with
cardiovascular diseases (CVDs). Two-sample Mendelian randomization was performed …

[HTML][HTML] Mendelian randomization analysis of 37 clinical factors and coronary artery disease in East Asian and European populations

K Wang, X Shi, Z Zhu, X Hao, L Chen, S Cheng… - Genome medicine, 2022 - Springer
Background Coronary artery disease (CAD) remains the leading cause of mortality
worldwide despite enormous efforts devoted to its prevention and treatment. While many …

Prediction of blood pressure changes over time and incidence of hypertension by a genetic risk score in Swedes

C Fava, M Sjögren, M Montagnana, E Danese… - …, 2013 - Am Heart Assoc
Recent Genome-Wide Association Studies (GWAS) have pinpointed different single
nucleotide polymorphisms consistently associated with blood pressure (BP) and …

Genome-wide association study in Chinese identifies novel loci for blood pressure and hypertension

X Lu, L Wang, XU Lin, J Huang… - Human molecular …, 2015 - academic.oup.com
Hypertension is a common disorder and the leading risk factor for cardiovascular disease
and premature deaths worldwide. Genome-wide association studies (GWASs) in the …

[HTML][HTML] Recapitulation of two genomewide association studies on blood pressure and essential hypertension in the Korean population

KW Hong, HS Jin, JE Lim, S Kim, MJ Go… - Journal of human …, 2010 - nature.com
Essential hypertension causes high rates of morbidity and mortality, primarily due to its
complications, and its development is regulated by genetic risk and environmental factors …

Type 2 diabetes and hypertension: a study on bidirectional causality

D Sun, T Zhou, Y Heianza, X Li, M Fan… - Circulation …, 2019 - Am Heart Assoc
Rationale: In observational studies, type 2 diabetes mellitus (T2D) has been associated with
an increased risk of hypertension, and vice versa; however, the causality between these …