Metastasizing cancer cells that arrest in brain microvessels have to face an organ
microenvironment that is alien, and exclusive. In order to survive and thrive in this foreign …

Metastasis is the relentless pursuit of cancer to escape its primary site and colonize distant
organs. This malignant evolutionary process is biologically heterogeneous, yet one unifying …

Metastatic lesions constitute the most frequently occurring malignancy in the brain, and their
detection portends a grim prognosis. Efforts to treat these lesions have failed partly because …

Our understanding of the process of metastatic progression has improved markedly over the
past decades, yet metastasis remains the most enigmatic component of cancer …

Brain metastasis, which commonly arises in patients with lung cancer, breast cancer and
melanoma, is associated with poor survival outcomes and poses distinct clinical challenges …

Brain metastasis is an important cause of morbidity and mortality in cancer patients. Hence,
the need to develop improved therapies to prevent and treat metastasis to the brain is …

Metastasis accounts for 90% of cancer-related mortality. Brain metastases generally present
during the late stages in the natural history of cancer progression. Recent advances in …

Cancer metastases into the brain constitute one of the most severe, but not uncommon,
manifestations of cancer progression. Several factors control how cancer cells interact with …

The metastasis of cancer to the central nervous system (CNS) remains a devastating clinical
reality, carrying an estimated survival time of less than one year in spite of recent therapeutic …

Metastasis to the central nervous system (CNS) remains a major cause of morbidity and
mortality in patients with systemic cancer. As the length of survival in patients with systemic …