Cytotoxic drugs remain the first-line option for cancer therapy but the development of drug-
resistance by tumor cells represents a primary obstacle for successful chemotherapy …

Autophagy is a conserved lysosomal degradation pathway where cellular components are
dynamically degraded and re-processed to maintain physical homeostasis. However, the …

Significance: In eukaryotes, autophagy represents a highly evolutionary conserved process,
through which macromolecules and cytoplasmic material are degraded into lysosomes and …

Macroautophagy (hereafter referred to as autophagy) is a lysosomal catabolic pathway
whereby cells recycle macromolecules and organelles. The capacity of autophagy to …

Neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease,
amyotrophic lateral sclerosis, prion diseases and polyglutamine disorders, including …

Autophagy is an evolutionarily conserved self-cannibalization process commonly found in
all eukaryotic cells. Through autophagy, long-lived or damaged organelles, superfluous …

Autophagy is a cellular degradative pathway that plays diverse roles in maintaining cellular
homeostasis. Cellular stress caused by starvation, organelle damage, or proteotoxic …

Autophagy is a mechanism by which cellular material is delivered to lysosomes for
degradation, leading to the basal turnover of cell components and providing energy and …

Autophagy is a lysosome-dependent intracellular degradation process that allows recycling
of cytoplasmic constituents into bioenergetic and biosynthetic materials for maintenance of …

Autophagy is a process of self-degradation that plays an important role in removing
damaged proteins, organelles or cellular fragments from the cell. Under stressful conditions …