Complex genetics and the etiology of human congenital heart disease

BD Gelb, WK Chung - Cold Spring …, 2014 - perspectivesinmedicine.cshlp.org
Congenital heart disease (CHD) is the most common birth defect. Despite considerable
advances in care, CHD remains a major contributor to newborn mortality and is associated …

Congenital heart disease: causes, diagnosis, symptoms, and treatments

RR Sun, M Liu, L Lu, Y Zheng, P Zhang - Cell biochemistry and biophysics, 2015 - Springer
The congenital heart disease includes abnormalities in heart structure that occur before
birth. Such defects occur in the fetus while it is developing in the uterus during pregnancy …

Epigenetics in congenital heart disease

G Wang, B Wang, P Yang - Journal of the American Heart …, 2022 - Am Heart Assoc
Embryonic heart development is an intricate process that mainly involves morphogens,
transcription factors, and cardiac genes. The precise spatiotemporal expression of these …

Genetics of congenital heart disease: past and present

I Muntean, R Togănel, T Benedek - Biochemical genetics, 2017 - Springer
Congenital heart disease is the most common congenital anomaly, representing an
important cause of infant morbidity and mortality. Congenital heart disease represents a …

Personalized genetic diagnosis of congenital heart defects in newborns

OM Diz, R Toro, S Cesar, O Gomez… - Journal of Personalized …, 2021 - mdpi.com
Congenital heart disease is a group of pathologies characterized by structural malformations
of the heart or great vessels. These alterations occur during the embryonic period and are …

The genetics of isolated congenital heart disease

SN Nees, WK Chung - … Journal of Medical Genetics Part C …, 2020 - Wiley Online Library
The genetic mechanisms underlying congenital heart disease (CHD) are complex and
remain incompletely understood. The majority of patients with CHD have an isolated heart …

[HTML][HTML] Navigating the non-coding genome in heart development and Congenital Heart Disease

G Chahal, S Tyagi, M Ramialison - Differentiation, 2019 - Elsevier
Abstract Congenital Heart Disease (CHD) is characterised by a wide range of cardiac
defects, from mild to life-threatening, which occur in babies worldwide. To date, there is no …

The genetics of congenital heart disease: a review of recent developments

CG Weismann, BD Gelb - Current opinion in cardiology, 2007 - journals.lww.com
The recent knowledge about the molecular genetic causes of congenital heart disease is
reviewed. In many instances, these gene discoveries are being rapidly translated into …

Development gone awry: congenital heart disease

PJ Gruber, JA Epstein - Circulation research, 2004 - Am Heart Assoc
Significant advances in the understanding of the molecular and genetic basis of congenital
heart disease have emerged from gene inactivation studies in mice and from human genetic …

Charting the path: navigating embryonic development to potentially safeguard against congenital heart defects

J Bragança, R Pinto, B Silva, N Marques… - Journal of Personalized …, 2023 - mdpi.com
Congenital heart diseases (CHDs) are structural or functional defects present at birth due to
improper heart development. Current therapeutic approaches to treating severe CHDs are …